Does Heart Hormone Help in Fat Metabolism

by Marixie Ann Obsioma, MT, undergrad MD on April 13, 2024
Last updated on April 13, 2024

Kicking off a reaction in our bodies similar to what happens when we get chilly, which melts away fat to keep us toasty, gets certain hormones buzzing. This research might just crack open new doors for creating medicines that help people with too much weight drop the extra pounds or help heart patients struggling with never-ending weight drop keep their weight stable.

Does Heart Hormone Help in Fat Metabolism

The researchers speculate that a rise in brown fat cells, which have been shown to protect against diet-induced obesity in laboratory trials, maybe a side effect of natriuretic peptides.

Obesity is caused by a breakdown in the metabolism of brown fat cells, which store fat tissue and rapidly transform food into energy.

According to Collins and her team’s findings, Natriuretic peptides have metabolic effects that rely heavily on the ratio between two different kinds of receptors — message-receiving proteins — on the surface of fat cells to be practical. 

Brown fat cells and white fat are both stimulated by the presence of the “signaling” receptor, known as NPRA. An additional “clearing” receptor known as NPRC appears to prevent natriuretic peptides from activating the first, increasing fat cells and adipose tissue in the white subcutaneous layer (WFC).

Natriuretic peptides were shown to be enhanced in the circulatory system of mice when they were exposed to cold in this investigation. The NPRA signaling receptor was shown to be more abundant in fat cells and fat tissue when compared to the NPRC clearance receptor, as well. Thus, it mobilized its activated fatty acids, and the calorie-burning brown fat machinery, leading to the observed changes in these animals. We don’t know precisely what changes the levels of different receptors.

As we learn more about how natriuretic peptides affect white fat cell mass, we may discover new therapeutic targets for treating obesity and metabolic disorders. It may aid obese patients’ weight loss by inhibiting the NRPC clearance receptor or developing drugs that encourage NPRA binding.

Understanding how this system operates could provide hope to individuals with persistent heart failure who suffer from cardiac cachexia, a severe body wasting that can develop. The presence of high amounts of natriuretic peptides in the bloodstream indicates the severity of heart failure. 

According to one theory, heart patients with cardiac cachexia may have unusually high amounts of brown fat formation and energy expenditure, leading to weight loss. Slowing or halting the production of peptides may be possible in these people. The Collins laboratory is currently preparing to conduct a laboratory test of this theory.

Calorie-Burning Brown Fat May Be Linked to a Heart Hormone

Brown fat is a form of fat that aids weight loss by burning calories rather than storing them as excess weight in your body.

Researchers now believe that hormones released by the heart may be able to increase the amount of brown fat found in adults.

According to the study, Cardiac Natriuretic Peptides, or CNPs, converted fat white cells to brown fat in mice.

According to a researcher at Sanford-Burnham Medical Research Institute in Orlando, the cardiac hormone may be vital to an effective weight loss treatment if studies indicate the same thing in humans.

The study has been published in the Journal of Clinical Investigation and is accessible online.

However, “we found in our study that these hormones also play a role in breaking down fat,” she explains.

Heart Rate and Brown Fat

When it comes to regulating fat storage and weight loss, Collins and his colleagues have studied the body’s adrenaline system for years.

Heart-derived hormones can stimulate the same fat-burning process as adrenaline, and the two systems can work together to increase the browning of fat cells, as demonstrated in their most recent work.

Cold exposure activated the brown fat-burning natriuretic peptide in the circulatory system of mice, promoting weight loss.

According to a separate human study published late last month, Brown fat has a calorie-burning capability when exposed to cold temperatures.

Researchers conducted tests on six volunteers in a cold room to quantify fat metabolism.

The men’s metabolic rate jumped by 80%, and they burnt an additional 250 calories over three hours when they became cold but did not shiver.

Brown fat burned conventional fat, increasing energy expenditure.

The Brown Fat Hype Exceeds Science’s Limitations

Weight loss treatments that increase brown fat or stimulate its fat-burning potential are the target of the research.

According to Yale Prevention Research Center director Dr. David Katz, the excitement surrounding brown fat therapies has outstripped the facts, and he is still skeptical that they are even practical.

It’s a place we’ve been before, he says. Regarding weight loss, “the likelihood of unintended effects is high” if we can stimulate brown fat, “two major ifs.”

When we focus on treating obesity quickly, we miss what has caused the epidemic of over-eating, and the under-exercising culture has caused it to worsen.

He argues that we would not be here if we didn’t have complex, overlapping metabolic defenses to ward off famine. Every time we think we’ve solved the problem, we’ve been proven wrong.

Five hormones greatly influence your weight, and this article will show you how to improve them.

Hormones are essential chemicals that play a significant role in the body by acting as chemical messengers.

They have a role in every physiological process, including regulating metabolism, appetite, and satiety. Some hormones have a crucial role in weight loss and maintenance because they connect to needs and other functions.

This article will discuss nine hormones that may influence your weight and provide suggestions for maintaining appropriate levels of those hormones.


Your pancreas is responsible for producing insulin, the primary storage hormone in your body. Insulin encourages the storage of glucose, a simple sugar that can be obtained from food, in the muscle, liver, and fat cells of healthy individuals to utilize later.

Insulin is secreted by your body in smaller amounts periodically throughout the day and in greater quantities after meals. Because insulin cannot transport glucose into the cells while you have this illness, you will have high blood sugar.

After that, your pancreas will create even more insulin to improve your body’s ability to absorb glucose.

Insulin resistance has been connected to obesity, which can have a role in other illnesses, such as type 2 diabetes and heart disease. Obesity has been associated with insulin resistance.

Many think of insulin sensitivity as the reverse of insulin resistance. Insulin resistance can be caused by diabetes. It indicates that your cells are receptive to the hormone insulin. As a result, it is wise to concentrate on lifestyle habits that help enhance insulin sensitivity, such as those listed below.

Tips to improve insulin sensitivity

  • Exercise regularly. Research supports movement at both high and moderate intensities to improve insulin sensitivity and decrease insulin resistance, then weight loss.
  • Have a better sleep. Not sleeping enough or having a quality sleep is linked to obesity and insulin resistance.
  • Omega-3. Those with metabolic disorders such as diabetes can benefit from omega-3’s ability to improve insulin sensitivity and decrease insulin resistance. Try increasing your fish intake, nuts, seeds, and plant oils if you’re not a fan of supplements.
  • Alter your diet. Try the Mediterranean diet — which includes many veggies and good fats from nuts. It will reduce insulin resistance and decrease your saturated and trans fats intake may also help.

Maintaining a healthy weight is essential. People who are overweight may benefit from healthy weight loss and weight control.

Choose carbs with a low glycemic index. Carbs can be a vital part of a healthy diet, but you should consume them in moderation. Whole grains, fruits, vegetables, and legumes are just a few examples.

Insulin resistance is a factor in developing chronic diseases such as type 2 diabetes and cardiovascular disease. Focus on maintaining a nutritious diet, improving your sleep patterns, and regularly exercising to improve insulin sensitivity.

Poor fat metabolism may also be caused by metabolic syndrome. Metabolic syndrome often always include dyslipidemia, hypertension and hyperglycemia. Obesity and insulin resistance are common causes of metabolic syndrome. Watch out for signs of metabolic syndrome always.


The hypothalamus, which is the part of your brain that controls hunger, gets the message from leptin, a hormone that causes fullness, that you have had enough to eat.

On the other hand, those who are obese are more likely to have leptin resistance. This implies that the signal to your brain to quit eating does not get through, which will eventually lead to you overeating.

As a result, your body may manufacture even more leptin until it reaches a level where it is considered high.

It is not understood what the natural origin of leptin resistance is; however, it could be linked to inflammation, gene mutations, or increased leptin synthesis, which can happen when someone is obese.

Tips for increasing leptin levels

Leptin resistance is not currently treatable, although a few lifestyle adjustments may help lower leptin levels:

  • Achieve a healthy body weight. Obesity is linked to leptin resistance, so maintaining a healthy body weight is vital. According to a study, a reduction in body fat may also help reduce leptin levels.
  • Improve the quality of your sleep. Obese adults may have lower levels of the hormone leptin, affecting their sleep quality. Obesity may not be directly linked to poor sleep, but there are countless other benefits.
  • Exercise regularly. Research links regular, consistent training to a decrease in leptin levels.

Resistance to the hormone leptin, which makes you feel full by decreasing your appetite, maybe the cause of overeating in obese persons. According to research, engaging in regular physical activity, getting adequate rest, and keeping a healthy body weight decrease leptin levels.


Ghrelin can be thought of as the antithesis of the hormone leptin. The hunger hormone conveys to your hypothalamus the information that your stomach is bare and requires nourishment to function correctly. Its primary purpose is to stimulate hunger and appetite.

In an average person, the hormone ghrelin levels are at their peak just before eating and at their lowest right after eating.

Research has shown that overweight people have lower levels of the hormone ghrelin, but they are more sensitive to the effects of the hormone. Because of this sensitivity, one could end up overeating.

Helping your body regulate its ghrelin level

It’s difficult to lose body weight when constantly hungry because calorie restriction often raises your ghrelin levels. Leptin levels also drop as a result of a slowed metabolism.

Here are some suggestions for reducing ghrelin levels to help curb hunger:

Maintain a healthy body weight range. If you are overweight, your sensitivity to ghrelin may increase, leading to an increased desire for food.

Make an effort to get adequate rest. Ghrelin levels rise due to sleep deprivation, which can contribute to hunger, overeating, and weight gain.

Eat frequently. You should eat when you’re hungry because ghrelin levels are at their maximum before a meal.

Those who are obese may be more sensitive to the effects of ghrelin, the hormone that triggers hunger. According to the findings of several studies, keep your body weight within a healthy range, and make sure you get enough sleep.


Cortisol, the stress hormone, is made by your adrenal glands and stored in the pituitary gland.

This hormone is the primary culprit for the elevated heart rate and energy levels seen in times of intense stress. The “fight or flight” reaction refers to the synthesis of the hormone cortisol and the release of adrenaline.

However, chronically high levels of cortisol have been related to various health problems, including diabetes, heart disease, low blood pressure, sleep issues, and an increased body mass.

Some components of one’s lifestyle, such as not getting enough sleep, persistent stress, and consuming many high-glycemic-index foods, may contribute to elevated cortisol levels.

In addition, obesity can raise cortisol levels, which can lead to weight growth, creating a vicious cycle.

Does metabolism affect blood pressure?

The influence of basal metabolic rate on blood pressure is established. Increased metabolism or metabolic rate can increase blood pressure and cause hypertension and other cardiovascular disease. Monitor your blood pressure always.

A guide to reducing your cortisol levels

You can lower your cortisol levels by making a few lifestyle changes:

  • Make sure you’re getting enough rest. High cortisol levels may be caused by chronic sleep disorders such as insomnia, restless leg syndrome, or sleep apnea. Focus on establishing a consistent bedtime and sleep routine.
  • Maintain a regular exercise schedule. Cortisol levels rise after intense activity, but regular exercise lowers them by improving overall health and reducing stress.
  • Try to be more mindful. Cortisol levels may be reduced by frequent mindfulness practice, but additional research is needed. It’s possible to incorporate meditation into your regular schedule.
  • Maintain a healthy weight range. Maintaining a healthy body weight may assist keep cortisol levels in line, as obesity may raise levels, and high levels of cortisol can lead to weight gain.
  • Diet should be well-rounded. According to research, increased cortisol levels have been linked to high-sugar, refined-grain, and saturated-fat diets. Additional benefits of eating a Mediterranean diet include lowering cortisol levels.

Although cortisol is an important hormone, persistently high levels can put a person at risk for obesity, cardiovascular disease or coronary artery disease, and diabetes. Consuming a balanced and healthy diet, engaging in regular physical activity, achieving an optimal amount of rest, and cultivating mindfulness may decrease your levels.


Estrogen is a type of sex hormone that controls not just the reproductive system of females but also the immunological system, the skeletal system, and the cardiovascular system.

This hormone fluctuates throughout the menstrual cycle and the many periods of life, such as pregnancy, lactation, and menopause.

People who are obese tend to have high amounts of estrogen, which is connected with an increased risk of some cancers and other chronic diseases. Obese people also tend to have higher levels of other hormones called androgens.

On the other hand, low levels, which are often associated with aging, perimenopause, and menopause, impact body weight and body fat, increasing the likelihood of suffering from chronic diseases.

Central obesity, which refers to an accumulation of weight around the body’s trunk, is a condition that frequently affects people whose estrogen levels are low. This can result in various health issues, including hyperglycemia, hypertension, and coronary heart disease.

Modifications to your lifestyle, most notably the maintenance of healthy body weight, can help you reduce your chance of developing many of these diseases and disorders.

Maintaining a healthy amount of estrogen is an essential part of overall wellness.

Try some of these methods to maintain a healthy estrogen balance:

  • Make an effort to keep a healthy body weight in check. Low estrogen levels in women between the ages of 55 and 75 may minimize the risk of heart disease through weight loss or maintenance. According to research, healthy weight maintenance has also been shown to reduce the risk of chronic diseases in general.
  • Maintain a regular exercise schedule. Working exercise may become more difficult if you suffer from low estrogen levels. No matter how intense your estrogen production gets, consistent training is critical to keeping your weight in check during menopause and other similar times.
  • Eat a well-balanced and healthy diet to avoid obesity. Studies have indicated that a diet substantial in red meat, processed foods, sweets, and refined grains raise estrogen levels, increasing your chance of developing chronic diseases, including heart disease and diabetes. You may want to limit your consumption of certain items. 

Because having high or low amounts of the sex hormone estrogen can cause weight gain and eventually raise your risk of disease, it is essential to maintain good lifestyle practices to keep these risks to a minimum and keep your weight healthy.

All of these hormones play a major role in weight loss. However, while watching out for these hormones, obese patients should also check other factors and processes, including fatty acid oxidation.

Increased fatty acid oxidation as it influences the ability of the body to reduce fat by diet and physical activity. Changes in this process were also linked to occurrence of obesity and several metabolic diseases. 


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